Bivalirudin vs Heparins With Bailout GP IIb/IIIa Inhibitors
Bivalirudin vs Heparins With Bailout GP IIb/IIIa Inhibitors
The data presented derive from a pre-specified but post-randomization analysis. The decision to use an upstream therapy with heparin only or heparin plus routine GPI was completely left to the discretion of the investigators and therefore, the equilibrium of randomization in baseline characteristics is potentially lost. Therefore, these results should be considered as hypothesis generating rather than definitive. Since enoxaparin was given in only 94 (8.4%) patients the results apply only to the use of UFH, which has been shown to be inferior to enoxaparin in the ATOLL trial. EUROMAX was an open-label trial due to the logistic difficulties related to implementation of complex antithrombotic regimens in the pre-hospital setting while rushing patients to primary PCI. However, all events were reviewed by a central adjudication committee blinded to treatment allocation.
Limitations
The data presented derive from a pre-specified but post-randomization analysis. The decision to use an upstream therapy with heparin only or heparin plus routine GPI was completely left to the discretion of the investigators and therefore, the equilibrium of randomization in baseline characteristics is potentially lost. Therefore, these results should be considered as hypothesis generating rather than definitive. Since enoxaparin was given in only 94 (8.4%) patients the results apply only to the use of UFH, which has been shown to be inferior to enoxaparin in the ATOLL trial. EUROMAX was an open-label trial due to the logistic difficulties related to implementation of complex antithrombotic regimens in the pre-hospital setting while rushing patients to primary PCI. However, all events were reviewed by a central adjudication committee blinded to treatment allocation.
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