Compartmentalization in Idiopathic Pulmonary Fibrosis
Although SP-A and SP-D are serum biomarkers of IPF having high homology, the current study suggests that the difference in hydrophilicity of the two proteins could be the cause of their difference in migration from the air space into the bloodstream. Because SP-D leaks into the circulation more easily, serum levels of SP-D may reflect pathological changes of the disease more sharply than those of SP-A.
Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
Conclusions
Although SP-A and SP-D are serum biomarkers of IPF having high homology, the current study suggests that the difference in hydrophilicity of the two proteins could be the cause of their difference in migration from the air space into the bloodstream. Because SP-D leaks into the circulation more easily, serum levels of SP-D may reflect pathological changes of the disease more sharply than those of SP-A.
Consent
Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
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