Bacille-Calmette-Guerin Non-Responders: How to Manage
A recently published phase II trial evaluated treatment response to nanoparticle albumin-bound paclitaxel (Abraxane®). The 28 patients who were enrolled had recurrent high-grade disease after at least on cycle of prior intravesical treatment BCG + intravesical chemotherapy and refused or were unfit for cystectomy. Nab-paclitaxel was administered weekly for 6 weeks and after CR continued on a monthly maintenance schedule for a total of 6 months. Initial response rate was 35.7% at 6 weeks defined as a negative biopsy and cytology. Recurrence-free survival was 30.6% at 2 years of follow-up.
Abraxane
A recently published phase II trial evaluated treatment response to nanoparticle albumin-bound paclitaxel (Abraxane®). The 28 patients who were enrolled had recurrent high-grade disease after at least on cycle of prior intravesical treatment BCG + intravesical chemotherapy and refused or were unfit for cystectomy. Nab-paclitaxel was administered weekly for 6 weeks and after CR continued on a monthly maintenance schedule for a total of 6 months. Initial response rate was 35.7% at 6 weeks defined as a negative biopsy and cytology. Recurrence-free survival was 30.6% at 2 years of follow-up.
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