Biomarkers for Disease Progression in Parkinson's Disease
This extensive systematic review has highlighted the methodological, statistical and reporting flaws of studies examining biomarkers for disease progression in Parkinson's disease. It is clear that continuing to publish small cross-sectional studies in this area is unlikely to yield significant results. We have suggested methodological guidelines which we hope will provide a better chance of making progress in this area, and would value feedback on them.
Conclusions
This extensive systematic review has highlighted the methodological, statistical and reporting flaws of studies examining biomarkers for disease progression in Parkinson's disease. It is clear that continuing to publish small cross-sectional studies in this area is unlikely to yield significant results. We have suggested methodological guidelines which we hope will provide a better chance of making progress in this area, and would value feedback on them.
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