PINK1: One Protein, Multiple Neuroprotective Functions
Mutations in the PINK1 gene are the second most frequent cause of autosomal recessive parkinsonism after Parkin, and can represent a risk factor towards sporadic Parkinson's disease. The PINK1 protein product has been implicated in several functions, mostly aimed at protecting neuronal cells against different types of stress. Growing evidence indicates that PINK1 interplays with other proteins mutated in familial forms of Parkinson's disease, such as Parkin, DJ-1 and α-synuclein. These interactions contribute to the definition of a complex scenario in which the mainteinance of mitochondrial homeostasis and the clearance of misfolded proteins and damaged organelles represent key neuroprotective processes. In this review, we summarize the current knowledge on PINK1 characteristics and functions, and analyze the network of functional relationships that link PINK1 to other Parkinson's disease-related proteins.
Summary
Summary
Mutations in the PINK1 gene are the second most frequent cause of autosomal recessive parkinsonism after Parkin, and can represent a risk factor towards sporadic Parkinson's disease. The PINK1 protein product has been implicated in several functions, mostly aimed at protecting neuronal cells against different types of stress. Growing evidence indicates that PINK1 interplays with other proteins mutated in familial forms of Parkinson's disease, such as Parkin, DJ-1 and α-synuclein. These interactions contribute to the definition of a complex scenario in which the mainteinance of mitochondrial homeostasis and the clearance of misfolded proteins and damaged organelles represent key neuroprotective processes. In this review, we summarize the current knowledge on PINK1 characteristics and functions, and analyze the network of functional relationships that link PINK1 to other Parkinson's disease-related proteins.
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