Ketamine and TMS Treatment for Bipolar II Disorder
Ketamine and TMS Treatment for Bipolar II Disorder
To the best of our knowledge, this is the first report of a successful treatment for bipolar II disorder using combined ketamine and TMS. Our patient reported ever-increased cognitive ability (including improved executive function) and improved affective regulation, which persisted even after the active treatment phase ended. In the future, a randomized controlled trial should be conducted to examine the efficacy of this combined treatment for the acute emotional and chronic cognitive consequences of bipolar disorders. Future work needs to further elucidate the possible mechanisms underlying combined ketamine and TMS treatment.
Conclusions
To the best of our knowledge, this is the first report of a successful treatment for bipolar II disorder using combined ketamine and TMS. Our patient reported ever-increased cognitive ability (including improved executive function) and improved affective regulation, which persisted even after the active treatment phase ended. In the future, a randomized controlled trial should be conducted to examine the efficacy of this combined treatment for the acute emotional and chronic cognitive consequences of bipolar disorders. Future work needs to further elucidate the possible mechanisms underlying combined ketamine and TMS treatment.
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