Nitric Oxide, Gene Expression and Lung Function in COPD
Variants in the NOS genes were not associated with lung function or COPD status. However, the G allele of rs1800779 resulted in a decrease of NOS3 gene expression and protein levels and this has implications for the numerous disease states that have been associated with this polymorphism. The rs1800779 polymorphism is also an excellent candidate for traits that are influenced by NO levels.
Conclusions
Variants in the NOS genes were not associated with lung function or COPD status. However, the G allele of rs1800779 resulted in a decrease of NOS3 gene expression and protein levels and this has implications for the numerous disease states that have been associated with this polymorphism. The rs1800779 polymorphism is also an excellent candidate for traits that are influenced by NO levels.
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