Time Frame

• Your puppy can start getting vaccines at five weeks. It will then have to go back to the vet and get more vaccines over the next several months.
  
  

Common Side Effects

• Just like with humans, vaccines are generally safe. The most common side effects are fever, loss of appetite and a soreness at the vaccination site. Generally, these symptoms will clear up in one day.
  
  

Uticaria

• Sometimes a puppy will develop uticaria, which is a skin reaction. Its symptoms include swelling and redness of the lips, eyes and neck, and it is very itchy. These symptoms usually develop within a couple of hours after the vaccination. If they do develop, take your puppy back to the vet for treatment.
  
  

Warning

• The most dangerous side effect is anaphylaxis. This is a rare but sudden reaction that can cause difficulty breathing, vomiting, diarrhea, seizures and cardiovascular disorders. It is life-threatening, but usually occurs within minutes of getting a vaccination. This is good because your puppy should still be at the vet's office so treatment can be done immediately.
  
  

Expected Results

• After receiving a vaccination, your puppy will likely be a little sluggish for a day or so. This is a normal reaction to vaccination, and your puppy will regain its normal disposition within a few days.