Typical Carcinoid Tumor of the Larynx in a Woman: A Case Report
Typical Carcinoid Tumor of the Larynx in a Woman: A Case Report
Introduction: Neuroendocrine tumors are the second most common neoplasms of the larynx. Histopathologically, neuroendocrine tumors can be classified into four types: typical carcinoid tumors, atypical carcinoid tumors, small cell neuroendocrine tumors and paragangliomas. Typical carcinoid tumor of the larynx is a particularly rare occurrence. We present a case of this rare disease, and review and discuss its diagnosis and treatment.
Case presentation: A 55-year-old Turkish woman presented with a two-year history of persistent hoarseness. Endoscopic laryngeal examination and computed tomography revealed a supraglottic mass. Direct laryngoscopy was performed and a biopsy taken. Results of the histopathologic examination and immunohistochemical analysis were consistent with typical carcinoid tumor of the larynx. A supraglottic laryngectomy was performed. There was no recurrence during a follow-up period of three years.
Conclusion: Carcinoid tumors require an accurate diagnosis because of their varied clinical behavior and prognosis. A correct pathologic diagnosis is essential, differentiating the tumors from other neuroendocrine neoplasms and medullary cancer of the thyroid gland. Immunohistochemical analysis is supplementary to a standard histopathologic evaluation. Currently, conservative surgical resection without elective neck dissection is the recommended treatment for typical carcinoid tumor of the larynx. Additional cases and case series with long-term follow-up will be useful for understanding the nature of this tumor and should clarify the prognosis.
Neuroendocrine tumors of the larynx are the second most common neoplasm of the larynx after squamous cell carcinomas. Four types of neuroendocrine tumor have been identified by the World Health Organization (WHO): typical carcinoid tumor, atypical carcinoid tumor, small-cell neuroendocrine carcinoma and paraganglioma. Carcinoid tumors and small cell neuroendocrine tumors originate from epithelium, whereas paragangliomas originate from neural tissue. Typical carcinoid tumors are less common than other neuroendocrine tumors of the larynx, with approximately 20 cases reported in the English language literature to date. We present an unusual case of typical carcinoid tumor of the larynx in a woman, and review the literature on neuroendocrine neoplasms of the larynx.
Abstract and Introduction
Abstract
Introduction: Neuroendocrine tumors are the second most common neoplasms of the larynx. Histopathologically, neuroendocrine tumors can be classified into four types: typical carcinoid tumors, atypical carcinoid tumors, small cell neuroendocrine tumors and paragangliomas. Typical carcinoid tumor of the larynx is a particularly rare occurrence. We present a case of this rare disease, and review and discuss its diagnosis and treatment.
Case presentation: A 55-year-old Turkish woman presented with a two-year history of persistent hoarseness. Endoscopic laryngeal examination and computed tomography revealed a supraglottic mass. Direct laryngoscopy was performed and a biopsy taken. Results of the histopathologic examination and immunohistochemical analysis were consistent with typical carcinoid tumor of the larynx. A supraglottic laryngectomy was performed. There was no recurrence during a follow-up period of three years.
Conclusion: Carcinoid tumors require an accurate diagnosis because of their varied clinical behavior and prognosis. A correct pathologic diagnosis is essential, differentiating the tumors from other neuroendocrine neoplasms and medullary cancer of the thyroid gland. Immunohistochemical analysis is supplementary to a standard histopathologic evaluation. Currently, conservative surgical resection without elective neck dissection is the recommended treatment for typical carcinoid tumor of the larynx. Additional cases and case series with long-term follow-up will be useful for understanding the nature of this tumor and should clarify the prognosis.
Introduction
Neuroendocrine tumors of the larynx are the second most common neoplasm of the larynx after squamous cell carcinomas. Four types of neuroendocrine tumor have been identified by the World Health Organization (WHO): typical carcinoid tumor, atypical carcinoid tumor, small-cell neuroendocrine carcinoma and paraganglioma. Carcinoid tumors and small cell neuroendocrine tumors originate from epithelium, whereas paragangliomas originate from neural tissue. Typical carcinoid tumors are less common than other neuroendocrine tumors of the larynx, with approximately 20 cases reported in the English language literature to date. We present an unusual case of typical carcinoid tumor of the larynx in a woman, and review the literature on neuroendocrine neoplasms of the larynx.
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