Kidney Dysfunction

• Kidney dysfunction can cause high blood potassium levels. Since potassium is excreted by the kidneys, potassium can build up when the kidneys do not function correctly, resulting in high blood potassium levels. Types of kidney dysfunction include chronic and acute kidney failure, transplant rejection, lupus nephritis and glomerulonephritis. Obstructive diseases that affect the urinary tract, such as urolithiasis, can also cause high blood potassium levels.
  
  

Medications

• Certain medications can cause a high blood potassium level. When the kidneys are not functioning properly, these medications can cause blood potassium levels to rise even more. Some medications that can cause high blood potassium levels include potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor blockers and non-steroidal anti-inflammatory drugs.
  
  

Severe Burns or Injury

• Severe burns or injuries can cause high blood potassium levels. When a person suffers these types of traumas, red blood cells are destroyed. The destruction of these cells can cause high blood potassium levels.
  
  

Alcohol or Drug Abuse

• Alcohol and drug abuse can cause high blood potassium levels. When a person abuses alcohol or drugs, their muscle fibers break down. When they break down, potassium is released into the bloodstream resulting in high blood potassium levels.
  
  

Adrenal Gland Diseases

• Adrenal gland diseases can cause high blood potassium levels. Adrenal gland disease that may cause high blood potassium levels include Cushing's syndrome and Addison's disease. Cushing's syndrome produces too much cortisol and Addison's disease does not produce enough cortisol. With the production of cortisol not being high or low enough, high blood potassium levels can occur.