Eplerenone in Patients at High Risk for Hyperkalemia
The excellent benefit-to-risk ratio of eplerenone in the subgroups in this analysis at high risk for developing hyperkalemia and/or worsening renal function with an excellent safety and tolerance combined with a substantial reduction of the combined endpoint of cardiovascular mortality and hospitalization for HF, presents compelling evidence for its use in all patients with HF-REF meeting the inclusion and exclusion criteria of the EMPHASIS-HF study. Even so, serum potassium and renal function have to be carefully monitored in these patients strictly selected to benefit from MRAs.
Conclusions
The excellent benefit-to-risk ratio of eplerenone in the subgroups in this analysis at high risk for developing hyperkalemia and/or worsening renal function with an excellent safety and tolerance combined with a substantial reduction of the combined endpoint of cardiovascular mortality and hospitalization for HF, presents compelling evidence for its use in all patients with HF-REF meeting the inclusion and exclusion criteria of the EMPHASIS-HF study. Even so, serum potassium and renal function have to be carefully monitored in these patients strictly selected to benefit from MRAs.
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