Intermittent Fasting for Prevention of Diabetes and CVD?
Intermittent fasting, in which individuals fast on consecutive or alternate days, has been reported to facilitate weight loss and improve cardiovascular risk. This review evaluates the various approaches to intermittent fasting and examines the advantages and limitations for use of this approach in the treatment of obesity and type 2 diabetes.
The increasing prevalence of obesity and type 2 diabetes in recent decades has been associated with increased comorbidities including atherosclerotic macrovascular disease and premature mortality. Individuals with sub-diabetic degrees of hyperglycaemia, such as IGT and IFG are also at increased risk of premature cardiovascular disease, emphasising the importance of interventions to improve glucose homeostasis in pre-diabetic, as well as diabetic individuals.
Several large studies have identified pre-diabetic individuals as subjects in whom to investigate lifestyle changes to prevent the progression to a fulminant diabetic state. However, there is considerable debate regarding the most effective manner in which lifestyle changes such as diet and/or exercise should be implemented. The approach of intermittent fasting is currently generating particular interest.
Abstract and Introduction
Abstract
Intermittent fasting, in which individuals fast on consecutive or alternate days, has been reported to facilitate weight loss and improve cardiovascular risk. This review evaluates the various approaches to intermittent fasting and examines the advantages and limitations for use of this approach in the treatment of obesity and type 2 diabetes.
Introduction
The increasing prevalence of obesity and type 2 diabetes in recent decades has been associated with increased comorbidities including atherosclerotic macrovascular disease and premature mortality. Individuals with sub-diabetic degrees of hyperglycaemia, such as IGT and IFG are also at increased risk of premature cardiovascular disease, emphasising the importance of interventions to improve glucose homeostasis in pre-diabetic, as well as diabetic individuals.
Several large studies have identified pre-diabetic individuals as subjects in whom to investigate lifestyle changes to prevent the progression to a fulminant diabetic state. However, there is considerable debate regarding the most effective manner in which lifestyle changes such as diet and/or exercise should be implemented. The approach of intermittent fasting is currently generating particular interest.
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