Monocyte chemotactic protein 1(MCP1) is the first one who discovered Class CC chemokine MCP family, it is the most intensively studied by scientists member, MCP1 plays some different physiological effects in the Class CC chemokine receptor 2 binding, such as induction of lymphocytes and natural killer cell homing, migration, activation, inflammation and angiogenesis. Studies have shown that MCP1 involved in a variety of inflammatory diseases, development, such as rheumatoid arthritis, diabetes. In recent years, MCP1 plays a important role in apoptosis and its mechanism have become the focus of many domestic and foreign scholars. Some findings have been confirmed MCP1 can upregulate apoptotic genes, MCP1 also activate JNK, p53 and other apoptosis-related signal transduction pathways. xcudchasdcbdjb
MCP1 mainly by the immune and non-immune cells, including monocytes, endothelial cells, smooth muscle cells, fibroblasts, astrocytes, small skin cells and certain tumor cells. These cells in the peripheral blood and tissues play an important anti-viral immune response. MCP1 mainly by mononuclear cells and regulates monocytes, memory T cells, natural killer cells and neutrophil migration and invasion, to raise its inflammatory foci in inflammation. However, only a small part of circulating lymphocytes are recruited to the lymph nodes. In addition, other chemokines are also involved in the recruitment of monocytes. MCP1 may be involved in angiogenesis process, beneficial or inhibit tumor growth, and MCP1 increases macrophage infiltration and macrophage-mediated angiogenesis.
MCP1 as an important chemokine involved in many physiological and pathological processes. Trail elisa kit http://www.cusabio.com/bio1-T-TRAIL-7-7.html played a key role in the mechanism of MCP1 detection, MCP1 for future molecular mechanisms of apoptosis-depth study provides a new direction. The results of the present study apoptosis-related diseases, clinical drug studies provide an experimental basis for clinical provides a new way of thinking.
Research and development of ciliary neurotrophic factor
Ciliary neurotrophic factor(CNTF) is an in vitro can promote neuronal survival chick ciliary protein, it belongs to the interleukin 26 (IL26) cytokine family members. CNTF has many functions, it can promote a variety of nerve cell survival, CNTF is the first one to be found to maintain in vivo and in vitro spinal motor neuron survival and neurite outgrowth neurotrophic factor. CNTF can induce a variety of nerve cell differentiation, reduce neuronal apoptosis and promote axonal regeneration. CNTF can protect neurons by degeneration of the retina and optic nerve damage, CNTF receptor location and mechanism similar to leptin. xcudchasdcbdjb
CNTF mainly in the central nervous system, CNTF concentration of less than the concentration of the peripheral nervous system, and its positive cells were mainly distributed in the cerebral cortex, olfactory bulb, cerebellum, subcortical areas. In the optic nerve and olfactory nerves, CNTF mRNA higher concentration, in addition to the synthesis of CNTF after brain injury increased rapidly, CNTF may be a central nervous system damage repair factor. Recent studies show a direct effect on the muscle CNTF nutrition, it is not only to maintain normal morphology and function of skeletal muscle, and can increase the number of muscle fibers, reduces the denervated muscle, aging and no load caused by the long-term muscle atrophy, decreased muscle strength and the changing nature of the muscle.
CNTF ELISA Kit uses a double antibody sandwich specimens CNTF levels. With purified CNTF antibody coated microtiter plate, made of solid phase antibody is bound by the monoclonal antibody are then added to the micropores CNTF, CNTF and then with HRP labeled antibody binding, the formation of antibody - antigen - enzyme-labeled antibody complex, after thorough washing TMB substrate color. TMB HRP enzyme catalyzed the conversion into the blue, and in the role of acid into the final yellow. The depth and color samples CNTF is positively correlated. With a microplate reader at 450nm wavelength absorbance (OD value), to the standard curve samples CNTF concentration.
MCP1 mainly by the immune and non-immune cells, including monocytes, endothelial cells, smooth muscle cells, fibroblasts, astrocytes, small skin cells and certain tumor cells. These cells in the peripheral blood and tissues play an important anti-viral immune response. MCP1 mainly by mononuclear cells and regulates monocytes, memory T cells, natural killer cells and neutrophil migration and invasion, to raise its inflammatory foci in inflammation. However, only a small part of circulating lymphocytes are recruited to the lymph nodes. In addition, other chemokines are also involved in the recruitment of monocytes. MCP1 may be involved in angiogenesis process, beneficial or inhibit tumor growth, and MCP1 increases macrophage infiltration and macrophage-mediated angiogenesis.
MCP1 as an important chemokine involved in many physiological and pathological processes. Trail elisa kit http://www.cusabio.com/bio1-T-TRAIL-7-7.html played a key role in the mechanism of MCP1 detection, MCP1 for future molecular mechanisms of apoptosis-depth study provides a new direction. The results of the present study apoptosis-related diseases, clinical drug studies provide an experimental basis for clinical provides a new way of thinking.
Research and development of ciliary neurotrophic factor
Ciliary neurotrophic factor(CNTF) is an in vitro can promote neuronal survival chick ciliary protein, it belongs to the interleukin 26 (IL26) cytokine family members. CNTF has many functions, it can promote a variety of nerve cell survival, CNTF is the first one to be found to maintain in vivo and in vitro spinal motor neuron survival and neurite outgrowth neurotrophic factor. CNTF can induce a variety of nerve cell differentiation, reduce neuronal apoptosis and promote axonal regeneration. CNTF can protect neurons by degeneration of the retina and optic nerve damage, CNTF receptor location and mechanism similar to leptin. xcudchasdcbdjb
CNTF mainly in the central nervous system, CNTF concentration of less than the concentration of the peripheral nervous system, and its positive cells were mainly distributed in the cerebral cortex, olfactory bulb, cerebellum, subcortical areas. In the optic nerve and olfactory nerves, CNTF mRNA higher concentration, in addition to the synthesis of CNTF after brain injury increased rapidly, CNTF may be a central nervous system damage repair factor. Recent studies show a direct effect on the muscle CNTF nutrition, it is not only to maintain normal morphology and function of skeletal muscle, and can increase the number of muscle fibers, reduces the denervated muscle, aging and no load caused by the long-term muscle atrophy, decreased muscle strength and the changing nature of the muscle.
CNTF ELISA Kit uses a double antibody sandwich specimens CNTF levels. With purified CNTF antibody coated microtiter plate, made of solid phase antibody is bound by the monoclonal antibody are then added to the micropores CNTF, CNTF and then with HRP labeled antibody binding, the formation of antibody - antigen - enzyme-labeled antibody complex, after thorough washing TMB substrate color. TMB HRP enzyme catalyzed the conversion into the blue, and in the role of acid into the final yellow. The depth and color samples CNTF is positively correlated. With a microplate reader at 450nm wavelength absorbance (OD value), to the standard curve samples CNTF concentration.
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